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CSU 54/2010: FIELD EFFICACY OF A NEW MOSAIC LONG-LASTING MOSQUITO NET (PERMANET� 3.0) AGAINST PYRETHROID-RESISTANT MALARIA VECTORS

Saturday, 8th of May 2010 Print
CSU 54/2010: FIELD EFFICACY OF A NEW MOSAIC LONG-LASTING MOSQUITO NET (PERMANET® 3.0) AGAINST PYRETHROID-RESISTANT MALARIA VECTORS
 
Is the 2 in 1 LLIN (with different insecticides applied to top and sides) the next step in combatting the development of pyrethroid resistance?
 
Good reading.
 
BD
 
 
Field efficacy of a new mosaic long-lasting mosquito net (PermaNet® 3.0) against pyrethroid-resistant malaria vectors: a multi centre study in Western and Central Africa

Vincent Corbel

1,2*, Joseph Chabi1,2, Roch D Dabiré3, Josiane Etang4, Philippe Nwane4, Olivier Pigeon5, Martin Akogbeto2, Jean-Marc Hougard6
1
Institut de Recherche pour le Développement (IRD), UR016, Caractérisation et Contrôle des Populations de Vecteurs, 01 BP 4414 RP Cotonou, République du Bénin, Tel : (+229) 21054141.
 
2 Centre de Recherche Entomologique de Cotonou (CREC), 06 BP 2604 Cotonou, République du Bénin, Tél. (+229) 21330825, Fax: (229) 21 37 49 81

3

Institut de Recherche en Sciences de la Santé (IRSS) / Centre Muraz (CM), 01 BP 390, Bobo-Dioulasso, Burkina Faso, Tel (+226) 20984147.

4

Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale (OCEAC), BP. 288, Yaoundé, Cameroon, Tel. (+237) 2232232.

5

Walloon Agricultural Research Centre (CRA-W), Agriculture and Natural Environment Department, Plant Protection Products and Biocides Physico-chemistry and Residues Unit, Rue du Bordia, 11 B-5030 , Gembloux, Belgium, Tel (+32) 81625262.

6

Institut de Recherche pour le Développement (IRD), BP 1386 Dakar, République du Sénégal, Tel : (+221) 338498332.

*Corresponding author

CV:

vincent.corbel@ird.fr, CJ: joseph.chabi@ird.fr, DKR: dabire_roch@hotmail.com, EJ: josyet@yahoo.fr

NP:

philino07@yahoo.fr, PO: pigeon@cra.wallonie.be, AM: akogbeto@yahoo.fr. HJM: jean-marc.hougard@ird.fr

Abstract below; full text at http://www.malariajournal.com/content/pdf/1475-2875-9-113.pdf

Background

Due to the spread of pyrethroid-resistance in malaria vectors in Africa, new strategies and tools are urgently needed to better control malaria transmission. The aim of this study was to evaluate the performances of a new mosaic long-lasting insecticidal net (LLIN), i.e. PermaNet® 3.0, against wild pyrethroid-resistant

Anopheles gambiae s.l. in West and Central Africa.

Methods

A multi centre experimental hut trial was conducted in Malanville (Benin), Vallée du Kou (Burkina Faso) and Pitoa (Cameroon) to investigate the exophily, blood feeding inhibition and mortality induced by PermaNet® 3.0 (i.e. a mosaic net containing piperonyl butoxide and deltamethrin on the roof) comparatively to the WHO recommended PermaNet® 2.0 (unwashed and washed 20-times) and a conventionally deltamethrin-treated net (CTN).

Results

The personal protection and insecticidal activity of PermaNet 3.0 and PermaNet® 2.0 were excellent (>80%) in the “pyrethroid-tolerant” area of Malanville. In the pyrethroid-resistance areas of Pitoa (metabolic resistance) and Vallée du Kou (presence of the L104F

kdr mutation), PermaNet® 3.0 showed equal or better performances than PermaNet® 2.0. It should be noted however that the deltamethrin content on PermaNet® 3.0 was up to twice higher than that of PermaNet® 2.0. Significant reduction of efficacy of both LLIN was noted after 20 washes although PermaNet® 3.0 still fulfilled the WHO requirement for LLIN.

Conclusion

The use of combination nets for malaria control offers promising prospects. However, further investigations are needed to demonstrate the benefits of using PermaNet® 3.0 for the control of pyrethroid resistant mosquito populations in Africa.


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