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- - - HEP B VACCINE IMMUNOGENICITY OUTSIDE THE COLD CHAIN

Sunday, 21st of April 2013 Print
  • HEP B VACCINE IMMUNOGENICITY OUTSIDE THE COLD CHAIN

Am J Trop Med Hyg. 2006 Feb;74(2):255-60.

Immunogenicity of a locally produced hepatitis B vaccine with the birth dose stored outside the cold chain in rural Vietnam.

Hipgrave DB, Tran TN, Huong VM, Dat DT, Nga NT, Long HT, Van NT, Maynard JE, Biggs BA.

Source

International Health Unit, Burnet Institute, Alfred Medical Research and Education Precinct, Prahran, Victoria, Australia.

Abstract

The heat stability of hepatitis B vaccine (HepB vaccine) should enable its storage outside the cold chain (OCC), increasing access to the birth dose in areas lacking refrigeration. We compared the immunogenicity of a locally produced vaccine among infants who received three doses stored within the cold chain (n = 358) or for whom the first dose was stored OCC for up to one month (n = 748). Serum was collected from these infants at age 9-18 months. The vaccine was protective in 80.3% of all infants. There were no differences in the prevalence of a protective level of antibody or antibody titer among groups of infants according to storage strategy. Differences in antibody titer between certain groups of infants could be explained by different vaccination schedules. Where birth dose coverage will be improved, HepB vaccine can be taken OCC for up to one month without affecting its immunogenicity.

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