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NEW THIS SUNDAY: PERSISTENCE OF TRANSMITTED HIV-1 DRUG RESISTANCE MUTATIONS

Thursday, 8th of August 2013

• NEW THIS SUNDAY: PERSISTENCE OF TRANSMITTED HIV-1 DRUG RESISTANCE MUTATION

1. 1.    Hannah Castro1,
2. 2.    Deenan Pillay2,
3. 3.    Patricia Cane3,
4. 4.    David Asboe4,
5. 5.    Valentina Cambiano5,
6. 6.    Andrew Phillips5,
7. 7.    David T. Dunn1,
8. 8.    for the UK Collaborative Group on HIV Drug Resistance

+ Author Affiliations

1.    ¹Medical Research Council Clinical Trials Unit, London, UK

2.    ²Division of Infection and Immunity, University College London, London, UK

3.    ³Virus Reference Department, Health Protection Agency, London, UK

4.    ⁴Directorate of HIV Medicine and Sexual Health, Chelsea and Westminster Hospital, London, UK

5.    ⁵Research Department of Infection and Population Health, University College London, London, UK

1. Corresponding author: Hannah Castro, Medical Research Council Clinical Trials Unit, Aviation House, 125 Kingsway, London, UK, WC2B 6NH. Tel: +44 (0)20 7670 4733, Fax: +44 (0)20 7670 4949, e-mail: h.castro@ctu.mrc.ac.uk
2. Alternate corresponding author: Dr David Dunn, Medical Research Council Clinical Trials Unit, Aviation House, 125 Kingsway, London, UK, WC2B 6NH. Tel: +44 (0)20 7670 4739, Fax: +44 (0)20 7670 4685, e-mail: d.dunn@ctu.mrc.ac.uk

J Infect Dis. (2013) doi: 10.1093/infdis/jit345 First published online: July 31, 2013

1. 2.      

Abstract below; full text is at http://jid.oxfordjournals.org/content/early/2013/07/31/infdis.jit345.full.pdf+html

There are few data on the persistence of individual transmitted HIV-1 drug resistance (TDR) mutations in the absence of selective drug pressure. We studied 313 patients in whom TDR mutations were detected at their first resistance test and who had a subsequent test performed whilst ART-naive. The rate at which mutations became undetectable was estimated using exponential regression accounting for interval censoring. Most thymidine analogue mutations (TAMs) and T215 revertants (but not T215F/Y) were found to be highly stable, with NNRTI and PI mutations being relatively less persistent. Our estimates are important for informing HIV transmission models.

© The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.