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NEW THIS FRIDAY: HEPATITIS E, A VACCINE-PREVENTABLE CAUSE OF MATERNAL DEATHS

Wednesday, 14th of August 2013 Print
  • HEPATITIS E, A VACCINE-PREVENTABLE CAUSE OF MATERNAL DEATHS

Emerg Infect Dis. 2012 Sep;18(9):1401-4. doi: 10.3201/eid1809.120241.

Labrique AB, Sikder SS, Krain LJ, West KP Jr, Christian P, Rashid M, Nelson KE.

Source

Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Rm E5543, Baltimore, MD 21205, USA. alabriqu@jhsph.edu

Abstract below; full text is at

http://wwwnc.cdc.gov/eid/article/18/9/12-0241_article.htm

Hepatitis E virus (HEV) is a major cause of illness and of death in the developing world and disproportionate cause of deaths among pregnant women. Although HEV vaccine trials, including trials conducted in populations in southern Asia, have shown candidate vaccines to be effective and well-tolerated, these vaccines have not yet been produced or made available to susceptible populations. Surveillance data collected during 2001-2007 from >110,000 pregnancies in a population of ≈650,000 women in rural Bangladesh suggest that acute hepatitis, most of it likely hepatitis E, is responsible for ≈9.8% of pregnancy-associated deaths. If these numbers are representative of southern Asia, as many as 10,500 maternal deaths each year in this region alone may be attributable to hepatitis E and could be prevented by using existing vaccines.

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