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NEW THIS TUESDAY: PREDICTORS OF MORTALITY AMONG TB-HIV COINFECTED PERSONS IN SW ETHIOPIA

Saturday, 31st of August 2013

PREDICTORS OF MORTALITY AMONG TUBERCULOSIS-HIV-COINFECTED PERSONS IN SOUTHWEST ETHIOPIA: A CASE-CONTROL STUDY

J Int Assoc Provid AIDS Care. 2013 Aug 21. [Epub ahead of print]

Deribe K, Yami A, Deribew A, Mesfin N, Colebunders R, Van Geertruyden JP, Woldie M, Maja T.

Source

Department of Epidemiology, Jimma University, Jimma, Ethiopia.

Abstract below; full text available to journal subscribers

Background:Tuberculosis (TB) remains the most common cause of death in people living with HIV/AIDS. The aim of the present study was to identify predictors of mortality in TB-HIV-coinfected patients.

Methods:We conducted an unmatched case-control study among a cohort of TB-HIV-coinfected adults who were on antiretroviral therapy (ART). Cases comprised 69 TB-HIV-coinfected patients who died during this period. For each case, we selected 3 (207) TB-HIV-coinfected patients who were alive during the end of the follow-up period.

Results:Male sex (odds ratio [OR] = 2.04, 95% confidence interval [CI]: 1.04-4.02), being bedridden at enrollment (OR = 2.84, 95% CI: 1.17-6.89), and cough of more than 2 weeks during initiation of ART (OR = 4.75 95% CI: 2.14-10.56) were the best predictors of mortality among TB-HIV-infected patients.Conclusion:Mortality among TB-HIV-coinfected patients accounted for a considerable number of deaths among the cohort. Patients with cough at ART initiation and with poor functional status should be strictly followed to reduce death.