Home >

REDESIGNED VACCINATION CARDS TO REDUCE DROPOUT RATES, PAKISTAN

Saturday, 7th of May 2011 Print

Should the vaccination card provide us with data (we already have those data in our registers) or to help the mother remember?

This cheap, easy redesign of the vaccination card turned it into a reminder card, with gratifying results.

Full text, with tables, is at http://www.ncbi.nlm.nih.gov/pubmed/21159080 and at
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-3156.2010.02698.x/pdf

Good reading.

BD

Randomized controlled trial to improve childhood immunization adherence in rural Pakistan: redesigned immunization card and maternal education

Hussain R. Usman1, Mohammad H. Rahbar2, Sibylle Kristensen1, Sten H. Vermund3,

Russell S. Kirby4, Faiza Habib5, Eric Chamot1

Article first published online: 15 DEC 2010

Tropical Medicine & International Health

Volume 16, Issue 3, pages 334–342, March 2011

Usman, H. R., Rahbar, M. H., Kristensen, S., Vermund, S. H., Kirby, R. S., Habib, F. and Chamot, E. (2011), Randomized controlled trial to improve childhood immunization adherence in rural Pakistan: redesigned immunization card and maternal education. Tropical Medicine & International Health, 16: 334–342. doi: 10.1111/j.1365-3156.2010.02698.x

Author Information

1  Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA

2  Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston, TX, USA

3  Vanderbilt University School of Medicine, Nashville, TN, USA

4  Community and Family Health, University of South Florida, FL, USA

5  Department of Pathology and Microbiology, Aga Khan University, Karachi, Pakistan

*Correspondence: Corresponding Author Hussain Raza Usman, Department of Epidemiology, University of Alabama at Birmingham, RPHB 430, 1530 3RD AVE S, Birmingham, AL 35294-0022, USA. Tel.: +1 205 975 7694; Fax: +1 205 934 8665; E-mail hussain@uab.edu

Summary

Objective  A substantial dropout from the first dose of diphtheria-tetanus-pertussis (DTP1) to the 3rd dose of DTP (DTP3) immunization has been recorded in Pakistan. We conducted a randomized controlled trial to assess the effects of providing a substantially redesigned immunization card, centre-based education, or both interventions together on DTP3 completion at six rural expanded programme on immunization (EPI) centres in Pakistan.

Methods  Mother-child pairs were enrolled at DTP1 and randomized to four study groups: redesigned card, centre-based education, combined intervention and standard care. Each child was followed up for 90 days to record the dates of DTP2 and DTP3 visits. The study outcome was DTP3 completion by the end of follow-up period in each study group.

Results  We enrolled 378 mother–child pairs in redesigned card group, 376 in centre-based education group, 374 in combined intervention group and 378 in standard care group. By the end of follow-up, 39% of children in standard care group completed DTP3. Compared to this, a significantly higher proportion of children completed DTP3 in redesigned card group (66%) (crude risk ratio [RR] = 1.7; 95% CI = 1.5, 2.0), centre-based education group (61%) (RR = 1.5; 95% CI = 1.3, 1.8) and combined intervention group (67%) (RR = 1.7; 95% CI = 1.4, 2.0).

Conclusions  Improved immunization card alone, education to mothers alone, or both together were all effective in increasing follow-up immunization visits. The study underscores the potential of study interventions’ public health impact and necessitates their evaluation for complete EPI schedule at a large scale in the EPI system.

Objectif:  Evaluer les effets d’une carte de vaccination profondément redessinée, l’éducation centrée ou les deux interventions ensemble sur la complétion du DTC3 dans six centres ruraux du Programme Elargi de Vaccination (PEV) au Pakistan.

Méthodes:  Essai randomisé contrôlé des unités maternelles-infantiles inscrites au DTC1 et randomisées en quatre groupes d’étude: carte redessinée, éducation centrée, intervention combinée et soins standards. Chaque enfant a été suivi pendant 90 jours pour enregistrer les dates de visites pour le DTC2 et le DTC3. L’objectif de l’étude était la complétion du DTC3 avant la fin de la période de suivi dans chaque groupe d’étude.

Résultats:  Nous avons recruté 378 unités maternelles-infantiles dans le groupe de la carte redessinée, 376 dans le groupe d’éducation centrée, 374 dans le groupe d’intervention combinée et 378 dans le groupe des soins standard. A la fin du suivi, 39% des enfants du groupe de soins standard avaient complété le DTC3. En comparaison, une proportion plus significative d’enfants ont complété le DTC3 dans le groupe de la carte redessinée (66%) (rapport de risque [RR] brut = 1,7; IC95%: 1,5–2,0), dans le groupe de l’éducation centrée (61%) (RR = 1,5; IC95%: 1,3–1,8) et dans le groupe d’intervention combinée (67%) (RR = 1,7; IC95%: 1,4–2,0).

Conclusions:  La seule amélioration de la carte de vaccination, la seule éducation des mères ou les deux ensembles étaient aussi efficaces pour augmenter les visites de vaccination durant le suivi. L’étude souligne l’impact potentiel sur la santé publique des études interventions et la nécessité de leur évaluation pour le schéma complet du PEV à grande échelle dans le système PEV.

Objetivo:  Evaluar los efectos de entregar un carnet de vacunación sustancialmente rediseñado, proveer educación materna o ambas intervenciones sobre el completar DTP3, en seis centros rurales del Programa Ampliado de Inmunizaciones (PAI) de Paquistán.

Métodos:  Ensayo aleatorizado y controlado, con unidades madre-hijo, incluidas en el momento de recibir DTP1 y aleatorizadas a uno de los cuatro grupos: carnet rediseñado, educación materna, intervención combinada y cuidados estándar. Cada niño fue seguido durante 90 días para tomar nota de las fechas de las visitas de DTP2 y DTP3. El principal resultado del estudio era el haber recibido la DTP3 al final del periodo de seguimiento en cada grupo de estudio.

Resultados:  Se incluyeron 378 unidades madre-hijo en el grupo del carnet de vacunación rediseñado, 376 en el grupo de educación materna, 374 en el grupo de intervención combinada y 378 en el grupo de cuidados estándar. Al final del periodo de seguimiento, un 39% de los niños en el grupo de cuidados estándar habían completado la DTP3. En comparación, una proporción significativamente mayor de niños completó la DTP3 en el grupo con el carnet de vacunación rediseñado (66%) (análisis crudo de razón de riesgos [RR] = 1.7; 95% IC = 1.5, 2.0), grupo de educación materna (61%) (RR = 1.5; 95% CI = 1.3, 1.8), y grupo de intervención combinada (67%) (RR = 1.7; 95% IC = 1.4, 2.0).

Conclusiones:  La mejora del carnet de vacunación, la educación maternal o ambas intervenciones juntas fueron todas efectivas a la hora de aumentar las visitas de seguimiento de la inmunización. El estudio subestima el potencial impacto sobre la salud pública de los estudios de intervención, y requiere de su evaluación con el calendario completo del PA,I a gran escala, dentro del sistema de PAI.

Introduction

The Expanded Programme on Immunization (EPI) offers a series of vaccines to children in Pakistan and many other WHO member states. These include Bacillus Calmette–Guérin (BCG) and oral polio vaccine (OPV) at birth, three doses of diphtheria–tetanus–pertussis (DTP)/OPV/hepatitis B virus (HBV) vaccines at 6, 10 and 14 weeks, and measles vaccine at 9 and 15 months after birth (WHO 2006). A countrywide network of EPI in Pakistan offers these vaccines to children at immunization centres at no cost, supplemented with outreach programmes in some areas.

A principal indicator of immunization coverage levels by the WHO is the completion of three doses of DTP vaccine (DTP3). With some contribution from outreach programmes, nationwide DTP3 coverage is primarily a function of the proportion of newborns that an immunization system brings in for the first immunization and the proportion of these children who return to the EPI centres for subsequent visits to complete DTP3. From 2002 to 2005, the WHO-reported DTP3 coverage in Pakistan was 65–72%. Socio-economically comparable countries in South-East Asia Region of the WHO have consistently achieved higher DTP3 levels than has Pakistan (WHO 2006). The BCG coverage (80–82% during 2002–2005) in Pakistan suggests that a high proportion of newborns receive EPI services, but a substantial proportion of these children fail to return for subsequent immunization visits. Despite progress in last two decades, it is unclear whether the measures currently in place in Pakistan will be sufficient to reach the desired national DTP3 coverage of more than 80%.

In 2003–2004, we designed a reminder-type immunization card and developed a centre-based information and motivation session for mothers/caregivers (henceforth referred to as ‘mothers’) for a randomized controlled trial to assess the effectiveness of providing these interventions on DTP3 completion at urban EPI centres in Pakistan (Usman et al. 2009). In the urban trial, we recorded 36% increase in DTP3 completion among children who received both redesigned card and centre-based education to mothers and 26% increase among children who received redesigned card only, compared with standard care group. Encouraged by the results of the urban study and considering urban rural disparities in literacy rate and socio-ethnic distribution in Pakistan, we conducted a second randomized controlled trial in 2005–2006 to test the effectiveness of same interventions at rural EPI centres in Pakistan.

Methods

The trial was conducted at six EPI centres located in the rural peripheries of Karachi, the capital city of Sindh Province. Study centres were selected from all rural centres around Karachi based on the highest volume of children vaccinated for DTP1 immunizations in the previous year.

Eligibility and enrolment

All children visiting the selected EPI centres for DTP1 were eligible to participate in the study, provided that the mother had been living in the area for the last 6 months or more. This criterion was used to exclude two groups of temporary residents: (i) women who temporarily relocated to their mothers’ houses to deliver their children and (ii) internally displaced families that had migrated to the study area to avoid the aftermath of 2005 earthquake in the north of Pakistan.

Given low literacy rates among women in rural Pakistan, a trained interviewer read out the consent form to the mother of each eligible child. For consenting mothers, the form was signed by the interviewer and a witness for enrolment. We used a pre-coded questionnaire at enrolment to record information from mothers on socio-demographic variables and factors potentially associated with immunization completion. The questionnaire addressed parents’ attributes (age at enrolment, education, occupation, monthly household income, ethnicity, family size, and mother’s age at marriage and first conception); child’s attributes (age at enrolment, sex and number of siblings); dates of DTP1-3 immunizations; and mode of transport and travel time to reach the EPI centre.

Randomization

The lead investigator provided a computer-generated randomization list to each enrolment centre. Each enrolled mother–child pair received an identification number (ID) from the randomization list and was assigned to the study group corresponding to the ID on the list. Because of the overt nature of interventions, neither the study participants nor the interviewers enrolling the study participants and recording the study outcome were blinded to the type of intervention received by the study participants.

Interventions

Redesigned card

The EPI card currently used in Pakistan has two main shortcomings. First, it is small (9 × 8.5 cm, when folded); hence, the information on child’s identity, immunization schedule, information for mothers and next immunization visit dates is crowded together and appears disorderly. Second, the next immunization date is hand-written by the EPI staff, often in very small and irregular letters. As a result, less-literate mothers have difficulties reading the date of their child’s next immunization. To address these issues, we designed a new simpler immunization card whose most important intended functions were to act as a constant reminder to mothers of the next immunization visit and to make it easy for them to locate and read the date of the next immunization. Much larger than the existing EPI card (15.5 × 11.5 cm when folded), the redesigned card was bright yellow in colour, placed in a plastic jacket and provided with a hanging string. On its outer sides, the card showed nothing but the next immunization date and day of the week for DTP2 and DTP3 visits written in a large font (Times New Roman 42, Microsoft Word®) using pre-printed stickers. Dedicated boxes were included on the inner sides of the folded card to record the remainder of the information (name of the EPI centre, card number, card’s date of issue, child’s name and address, complete immunization schedule dates and instructions to the mothers). Despite a small purchase volume, the cost of each card including the plastic jacket was US$ 0.05 (Pakistani Rupees 3).

Centre-based education

In Pakistan, there is no standardized procedure describing how the EPI staff should inform mothers about subsequent immunization visits. Because mother’s lack of information might contribute to childhood immunization dropouts, the second intervention (centre-based education) was designed as a 2–3 min conversation with mother to convey the importance of the completion of immunization schedule and to explain the potential adverse impact of incomplete immunization on child’s health. The session was in simple vocabulary in the local language (Urdu) and deliberately kept short in prevision of potential large-scale use by EPI staff in the future.

Trial design

Mother–child pairs were randomly allocated to three intervention and one standard care groups. Interventions were provided in a private space to prevent contamination between study groups.

At enrolment in the first intervention group (‘Redesigned card’), a trained interviewer pasted the upcoming date and day of DTP2 immunization on both outer sides of the card and showed it to the mother. Mother was asked to hang the card in her home at a frequently visible place and requested that she bring the card along on her next immunization visit to the EPI centre. At DTP2 visit, the interviewer crossed out the date and day for DTP2 visit to avoid any confusion to the mothers, pasted the date and day for the upcoming DTP3 immunization visit on both sides of the card and showed the information to the mother. Mothers in the second intervention group (‘Centre-based education’) received centre-based education from trained study interviewers. Mothers in the third intervention group (‘Combined intervention’) received both the redesigned card and centre-based education in exactly the same way as described above. Finally, mothers of the fourth group (‘Standard care’) underwent routine EPI centre visit and received neither intervention.

Follow-up

We followed up each study child at the EPI centre for 90 days from the day of enrolment at DTP1. Because each DTP2 and DTP3 were scheduled at 30-day intervals after DTP1 by EPI schedule, both DTP2 and DTP3 could be completed ideally within 60 days after the DTP1 visit. During the study period, interviewers screened every child who visited their study centres and recorded DTP2 and DTP3 dates of study children.

Study outcome

The study outcome was the immunization status of each child at the end of day 90 post-enrolment. The immunization status was dichotomized into completion of both DTP2 and DTP3 (termed ‘DTP3 completed’) and all others (termed ‘DTP3 not completed’).

Statistical methods

Sample size was calculated for the comparison of two proportions. Assuming DTP3 completion of 75% in the standard care group, we calculated that a sample size of 375 subjects in each study group would be sufficient to detect ≥ 10% higher DTP3 completion in any one of the intervention groups than in the standard care group with 90% power and 5% unadjusted type 1 error.

All analyses were performed using SAS® version 9.1 (SAS Institute, Inc., Cary, NC, USA) and were by intention to treat. To determine how successful the randomization process had been, we compared frequencies and percentages of participants’ baseline characteristics across study groups. The main independent variable was the type of intervention with the four study group categories. The immunization status coded ‘1’ for ‘DTP3 completed’ and ‘0’ for ‘DTP3 not completed’ was the dependent variable. In primary analysis, we computed crude risk ratios (RRs) and their 95% confidence intervals (CIs) by univariate log-binomial regression (SAS® PROC GENMOD) to assess the effect of each intervention on DTP3 completion (Wacholder 1986; Zocchetti et al. 1995; Skov et al. 1998; Spiegelman & Hertzmark 2005).

Because of important socio-economic, literacy and cultural differences between Mohajir and non-Mohajir ethnicities, we evaluated the evidence of effect-measure modification by ethnicity on the effectiveness of interventions. The hypothesis for secondary analysis was conceived during the data analysis phase of the study. For this secondary analysis, we used log-binomial regression to compute crude and adjusted risk ratios separately among Mohajir and non-Mohajir ethnicities (Wacholder 1986; Zocchetti et al. 1995; Skov et al. 1998; Spiegelman & Hertzmark 2005). Because multivariable model constructed among Mohajirs failed to converge, the final model was reconstructed using multivariable Poisson regression with robust variance (Zou 2004; Spiegelman & Hertzmark 2005).

Approval for this study was obtained from the Ethical Review Committee (ERC) of the Aga Khan University (AKU), Karachi, Pakistan, and the Institutional Review Board (IRB) of the University of Alabama at Birmingham (UAB).

Results

Of 2,371 mother–child pairs screened for eligibility between November 2005 and May 2006, 861 (36%) were excluded because they had arrived in the area within the past 6 months and four (0.2%) because they refused to participate (Figure 1). Enrolment was concluded after random allocation of 1506 study participants to four study groups. The follow-up of the last study child enrolled in the study was completed in August 2006. Because the study participants who had not returned to the centres within 90 days of their DTP1 visit were considered DTP3 not completed, no study participant was considered lost to follow-up. In multivariable analysis, we excluded 15 children from the redesigned card group, 11 from the centre-based education group, 7 from the combined intervention group and 12 from the standard care group because of missing child’s age at enrolment.

Figure 1.  Flow of study participants.

 

The majority of informants in all study groups (77–81%) were mothers; most of the other interviewees were other female caretakers, including grandmothers and aunts. The distribution of participants’ socio-demographic characteristics at enrolment was similar (P > 0.05) across study groups except for maternal age (P = 0.03; Table 1).

Table 1.   Distribution among study groups of socio-demographic characteristics of study participants at enrolment (Pakistan, 2005–2006)

Variables

Redesigned card n = 378 Column %

Centre-based education n = 376 Column %

Combined intervention n = 378 Column %

Standard care n = 376 Column %

EPI centre of enrolment

 A

25

25

25

25

 B

17

20

18

19

 C

7

6

5

5

 D

28

28

33

30

 E

6

5

3

4

 F

17

16

17

17

Mother of child as respondent

77

81

79

80

Ethnicity

 Mohajir

15

14

13

16

 Pashto

33

31

33

32

 Punjabi

13

16

14

11

 Hindko

19

19

20

18

 Sindhi

9

9

11

13

 Others

11

12

9

11

Child’s age at enrolment (days)

 ≤60

58

57

64

57

 >60

38

40

34

40

 Missing

4

3

2

3

Boys enrolled

51

49

53

49

Total number of living children in the family

 One

28

22

24

28

 Two

25

20

27

21

 Three or more

47

57

49

51

Mother’s age at enrolment (years)

 ≤19

10

6

9

8

 20–29

70

64

64

68

 >29

20

30

27

24

Mother’s years of formal schooling

 ≥6

26

27

26

26

 1–5

18

17

19

17

 0

56

57

55

57

Mother a housewife

96

99

98

98

Father’s years of formal schooling

 ≥6

53

49

56

54

 1–5

15

17

11

13

 0

32

35

32

33

≤5 household members

28

27

23

23

Monthly household income (Pakistani Rupees)

 0–5000

64

55

62

60

 >5000

36

45

38

40

Television in home

57

53

56

54

Mode of transport to EPI centre

 Public bus system

5

9

6

6

 Privately owned or rented motor vehicles

10

8

6

7

 On foot

85

84

88

87

≤5 min to reach EPI centre from home

20

22

19

17

By the end of follow-up, 39% of children in the standard care group completed DTP3 (Table 2). Compared to this, a significantly higher proportion of children completed DTP3 in the redesigned card group (66%) (crude risk ratio [RR] = 1.7; 95% CI = 1.5, 2.0), the centre-based education group (61%) (RR = 1.5; 95% CI = 1.3, 1.8) and the combined intervention group (67%) (RR = 1.7; 95% CI = 1.4, 2.0).

Table 2.   Crude risk ratios (RRs) and 95% confidence intervals (CIs) for DTP3 completion by intervention group (Pakistan, 2005–2006)

Study groups

Total

DTP3 completed during 90 days of follow-up n (%)

Crude RR

95% CI

RR, risk ratio; CI, confidence interval.

*A risk ratio of 1.0 indicates the reference category.

Redesigned card

378

252 (67)

1.7

(1.5, 2.0)

Centre-based education

376

228 (61)

1.5

(1.3, 1.8)

Combined intervention

374

245 (66)

1.7

(1.4, 2.0)

Standard care

378

149 (39)

1.0*

 

In secondary analysis, after adjusting for child’s age at enrolment and mother’s formal years of schooling, a significantly higher proportion of Mohajir children completed DTP3 in the redesigned card group (adjusted risk ratio [Adj. RR] = 3.0; 95% CI = 1.7, 5.3), the centre-based education group (Adj. RR = 3.3; 95% CI = 1.9, 5.8) and the combined intervention group (Adj. RR = 3.0; 95% CI = 1.7, 5.4) compared with the standard care group (Table 3). Although interventions were also effective among non-Mohajir children, the individual or combined effects of interventions on DTP3 completion were much weaker than among Mohajir children.

Table 3.   Crude and adjusted risk ratios (RRs) with 95% confidence intervals (CIs) for DTP3 completion by intervention group among Mohajir and non-Mohajir children (Pakistan, 2005–2006)

 

Study groups

Total

DTP3 completed during 90 days of follow-up n (%)

Crude RR

95% CI

Adjusted RR

95% CI

RR, risk ratio; CI, confidence interval.

Multivariable model adjusted for child’s age at enrolment and mother’s years of formal schooling. Child’s age at enrolment was not available for one child each in group 1, group 2 and group 3 among Mohajirs and 14 children in group 1, 10 in group 2, 6 in group 3 and 12 in group 4 among non-Mohajirs.

All pairwise comparisons: P < 0.01

*A risk ratio of 1.0 indicates the reference category

Mohajir

Redesigned card

56

46 (82)

3.0

(2.0, 4.7)

3.0

(1.7, 5.3)

Centre-based education

51

46 (90)

3.3

(2.2, 5.1)

3.3

(1.9, 5.8)

Combined intervention

49

40 (82)

3.0

(1.9, 4.7)

3.0

(1.7, 5.4)

Standard care

59

16 (27)

1.0†

 

1.0†

 

Non-Mohajir

Redesigned card

322

206 (64)

1.5

(1.3, 1.8)

1.5

(1.3, 1.8)

Centre-based education

325

182 (56)

1.3

(1.1, 1.6)

1.3

(1.1, 1.6)

Combined intervention

325

205 (63)

1.5

(1.3, 1.8)

1.5

(1.3, 1.7)

Standard care

319

133 (42)

1.0*

 

1.0*

 

Discussion

Our results suggest that providing an inexpensive reminder type immunization card or a short centre-based education to mothers is effective intervention for increasing subsequent immunization visits to the EPI centres. We found no evidence that providing both interventions in combination was superior to providing the redesigned immunization card alone.

Compared to our urban trial (Usman et al. 2009), study interventions were more effective at rural EPI centres and resulted in higher percentage increase in DTP3 completion in all three intervention groups. In a resource-constrained setting such as Pakistan, policy makers may prefer implementing the proposed interventions first in rural areas. However, the implementation of these interventions at a large scale may be more cost-effective in urban areas owing to lower administrative and training costs for comparatively high volume and geographically closer urban EPI centres.

In both urban and rural trials, providing redesigned card alone was more effective than education alone in increasing DTP3 completion. Further, combining two interventions at urban centres resulted in even higher DTP3 completion. However, at rural centres, combined effect of two interventions was not higher than the effect of redesigned card alone. This may indicate that a structural intervention such as the redesigned immunization card is best suited for lower literacy rural areas and can achieve the maximum benefit even if implemented without the centre-based education to mothers.

In developing countries, successful supply-side interventions have used different approaches to improve staff performance such as enhanced monitoring and supervision (Van Zwanenberg & Hull 1988), training in a classroom (Main et al. 2001) or training by peers in the field (Robinson et al. 2001). Other effective supply-side approaches focused on increasing access to immunization by making modifications to the vaccination schedule (e.g. delivering vaccines earlier or at shorter intervals) (Chen 1976, 1989; Maher et al. 1993), reorganizing clinic procedures to shorten waiting times (Ekunwe 1984), and bringing immunization services closer to the people using outreach teams (Dominguez Uga 1988; Coetzee et al. 1993; San Sebastian et al. 2001), or community health workers (Alto et al. 1989).

Interventions that have proved effective in stimulating the demand in resource-poor settings for vaccination among children with incomplete immunization include reminders sent to the home of target children (Kuhn & Zwarenstein 1990) and door-to-door household visits to notify parents that their child is late for a vaccine (Cutts et al. 1990; Brugha & Kevany 1996). Redesigning the immunization card for reducing immunization dropouts has not received attention in developing countries. Reviews of published studies (Pegurri et al. 2005) and grey literature (Batt et al. 2004) on strategies to improve childhood immunization coverage in low- and middle-income countries could not identify any study attempting to redesign the immunization card and evaluating its impact on immunization visits. Interventions assessed in our published urban trial (Usman et al. 2009) and this rural trial attempted to increase demand by targeting children who are already in the EPI system. We believe that these studies are a major step forward in demonstrating potential large-scale impact of proposed interventions to the policy makers.

The redesigned immunization card tested in this study has several characteristics that make it an appealing and viable option to improve the vaccine delivery system in rural Pakistan. Because the new card was designed considering the sparse level of EPI staffing and the additional cost incurred to the EPI system, we believe that the large-scale implementation of the new card in the EPI system would not require any additional work from EPI staff and only minimally add to the cost per child immunized. Based on our study estimates of DTP3 completion among the redesigned card and standard care groups (Table 2), a countrywide implementation of the redesigned card in rural areas could potentially translate into more than half a million additional children immunized for DTP3 in an annual rural Pakistani birth cohort of 2.8 million children (Pakistan 2003). Another spinoff benefit of using the redesigned card in the EPI system could be that mothers may retain the new card for a longer period owing to its plastic jacket and larger size, resulting in more accurate estimation of immunization coverage by cross-sectional surveys. At present, these surveys rely heavily on mother’s recall as the existing EPI card is usually not available with the majority of mothers at the time of interview (Mukanga & Kiguli 2006; Torun & Bakirci 2006).

In secondary analysis, we observed that the effects of redesigned card and centre-based education on DTP3 completion were substantially stronger among Mohajir than among non-Mohajir ethnicities (Table 3). The underlying reason for this effect-measure modification by ethnicity is unclear. We explored whether more years of schooling among Mohajir mothers might have played a role in responding more positively to the interventions. However, adjusting for mother’s years of formal schooling did not affect the differences in the effect of interventions between the two ethnic groups. Future studies should further explore this differential responsiveness of ethnic groups to such interventions.

A limitation of our study is that the follow-up of study children for return visits was carried out only at the study centres for a limited period of 90 days. There is a chance that a small proportion of children might have returned to the study centres after the follow-up period or visited non-study EPI centres for DTP2 or DTP3. Nonetheless, we do not have any evidence suggesting higher occurrence of this in standard care group given the randomized design of our study and assume that it did not affect the internal validity of the study. Additionally, survival curves of days to DTP3 for each study group (data not shown) indicated a plateau at around 80 days of follow-up, making it unlikely that a large number of children might have returned for DTP3 after 90 days.

WHO reported coverage of 82% for DTP1 and 72% for DTP3 in Pakistan for 2005. This suggests that 88% (72/82*100) of children who received DTP1 went on to complete DTP3; in contrast, no more than 39% of the children enrolled in the standard care group of our study completed DTP3 in 90 days of follow-up (Table 2). Comparison of these figures must be made with caution because our study estimates are from a cohort of children followed up at EPI centres, whereas the WHO estimates were calculated using DTP1 and DTP3 coverage. Additionally, dropouts in the rural areas where our study was conducted are also likely to be higher than the country-level estimates reported by the WHO because of lower socio-economic conditions in rural areas of Pakistan. Nonetheless, the reasons discussed above might not fully explain the wide gap between the study and the WHO estimates, and the possibility of WHO overestimating childhood immunization in Pakistan cannot be ruled out (Murray et al. 2003).

As a result of limited time and resources, we tested the effect of study interventions only on two follow-up immunization visits (DTP2 and DTP3) scheduled after DTP1. Because complete EPI schedule in Pakistan has five follow-up visits (DTP1, DTP2, DTP3, measles 1 and measles 2) after BCG at birth, it is difficult to predict the effectiveness of proposed interventions for the complete EPI schedule. Furthermore, low immunization coverage cannot be effectively addressed solely by reducing the dropouts; interventions to bring more newborns in the EPI system are equally important.

In conclusion, this study offers strong evidence that redesigned immunization card was effective in enhancing subsequent infant vaccine visits. Because this low-cost intervention has the potential to yield considerable benefits for children, the next step will be to evaluate it for complete EPI schedule at a large scale in the EPI system.

Acknowledgements

This study was funded by the Sparkman Center for Global Health and NIH grant D43TW005497, the University of Alabama at Birmingham-Aga Khan University International Maternal and Child Health Research and Training (IMCHRT) program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We thank EPI Sindh, Pakistan, for granting permission and extending cooperation for this study.

References

Alto WA, Alk S, Pinau D & Polume H (1989) Improving immunization coverage, a comparison between traditional MCH teams and MCH teams plus aid post orderlies. Papua New Guinea Medical Journal 32, 97–100.

Batt K, Fox-Rushby JA & Castillo-Riquelme M (2004) The costs, effects and cost-effectiveness of strategies to increase coverage of routine immunizations in low- and middle-income countries: systematic review of the grey literature. Bulletin of the World Health Organization 82, 689–696.

Brugha RF & Kevany JP (1996) Maximizing immunization coverage through home visits: a controlled trial in an urban area of Ghana. Bulletin of the World Health Organization 74, 517–524.

Chen ST (1976) The improvement of immunization coverage by early immunisation of children in Malaysia. Medical Journal of Malaysia 31, 17–19.

Chen ST (1989) Influence of immunization schedule on immunization coverage. The Journal of Tropical Medicine and Hygiene 92, 386–390.

Coetzee DJ, Ferrinho P & Reinach SG (1993) A vaccination survey using the EPI methodology to evaluate the impact of a child health outreach programme in an urban area of South Africa. Bulletin of the World Health Organization 71, 33–39.

Cutts FT, Phillips M, Kortbeek S & Soares A (1990) Door-to-door canvassing for immunization program acceleration in Mozambique: achievements and costs. International Journal of Health Services 20, 717–725.

Dominguez Uga MA (1988) Economic analysis of the vaccination strategies adopted in Brazil in 1982. Bulletin of the Pan American Health Organization 22, 250–268.

Ekunwe EO (1984) Expanding immunization coverage through improved clinic procedures. World Health Forum 5, 361–363.

Kuhn L & Zwarenstein M (1990) Evaluation of a village health worker programme: the use of village health worker retained records. International Journal of Epidemiology 19, 685–692.

Maher CP, Hall JJ, Yakam W, Naupa M & Leonard D (1993) Improving vaccination coverage: the experience of the Expanded Programme on Immunization in Vanuatu. Papua New Guinea Medical Journal 36, 228–233.

Main B, Lower T, James R & Rouse I (2001) Changes in Expanded Program for Immunization coverage for mother and child in Krakor, Cambodia 1996--1998. Tropical Medicine and International Health 6, 526–528.

References

Mukanga DO & Kiguli S (2006) Factors affecting the retention and use of child health cards in a slum community in Kampala, Uganda, 2005. Maternal and Child Health Journal 10, 545–552.

Murray CJ, Shengelia B, Gupta N, Moussavi S, Tandon A & Thieren M (2003) Validity of reported vaccination coverage in 45 countries. Lancet 27, 1022–1027.

Pakistan Demographic Survey (2003) Accessed February 6, 2008 at http://www.statpak.gov.pk/depts/fbs/statistics/pds2001/pds2001.html.

Pegurri E, Fox-Rushby JA & Damian W (2005) The effects and costs of expanding the coverage of immunisation services in developing countries: a systematic literature review. Vaccine 23, 1624–1635.

Robinson JS, Burkhalter BR, Rasmussen B & Sugiono R (2001) Low-cost on-the-job peer training of nurses improved immunization coverage in Indonesia. Bulletin of the World Health Organization 79, 150–158.

San Sebastian M, Goicolea I, Aviles J & Narvaez M (2001) Improving immunization coverage in rural areas of Ecuador: a cost-effectiveness analysis. Tropical Doctor 31, 21–24.

Skov T, Deddens J, Petersen MR & Endahl L (1998) Prevalence proportion ratios: estimation and hypothesis testing. International Journal of Epidemiology 27, 91–95.

Spiegelman D & Hertzmark E (2005) Easy SAS calculations for risk or prevalence ratios and differences. American Journal of Epidemiology 162, 199–200.

Torun SD & Bakirci N (2006) Vaccination coverage and reasons for non-vaccination in a district of Istanbul. BMC Public Health 6, 125.

Usman HR, Akhtar S, Habib F & Jehan I (2009) Redesigned immunization card and center-based education to reduce childhood immunization dropouts in urban Pakistan: a randomized controlled trial. Vaccine 27, 467–472.

van Zwanenberg TD & Hull C (1988) Improving immunisation: coverage in a province in Papua New Guinea. British Medical Journal (Clinical Research Ed.) 296, 1654–1656.

Wacholder S (1986) Binomial regression in GLIM: estimating risk ratios and risk differences. American Journal of Epidemiology 123, 174–184.

WHO (2006) Vaccines and Biologicals: WHO Vaccine Preventable Diseases: Monitoring System. 2006 Global Summary, WHO, Geneva.

Zocchetti C, Consonni D & Bertazzi PA (1995) Estimation of prevalence rate ratios from cross-sectional data. International Journal of Epidemiology 24, 1064–1067.

Zou G (2004) A modified poisson regression approach to prospective studies with binary data. American Journal of Epidemiology 159, 702–706.

 



--
To subscribe or unsubscribe from these Child Survival Updates, pls contact kidsurvival@gmail.com. If you unsubscribe, indicate from which E mail address you are receving these updates.
 
When subscribing, write from your most permanent E-mail address, not always that of your current employer.
 
Do not subscribe on behalf of friends or colleagues; forward updates to them for their decision.

Those wishing to read only malaria updates should subscribe at
kidsurvivalmalaria@gmail.com
 

Those wishing to read only vaccination updates should subscribe at kidsurvivalvaccination@gmail.com
 
READER COMMENTS
 
If you have a comment you want posted, send to rdavis@africamail.com
WEBPAGE
 
These updates are also available at www.childsurvival.net  
(C) All Rights Reserved - Child Survival.net