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Vaccine associated paralytic poliomyelitis cases from children presenting with acute flaccid paralysis in Uganda

Thursday, 7th of January 2016 Print

Vaccine associated paralytic poliomyelitis cases from children presenting with acute flaccid paralysis in Uganda

  1. Mary B. Nanteza1,*
  2. Annet Kisakye2,
  3. Martin O. Ota3
  4. Nicksy Gumede3,
  5. Josephine Bwogi1 and
  6. the Expanded Program on Immunization Laboratory Team - Uganda Virus Research Institute (EPI LAB - UVRI)1

Article first published online: 16 JUL 2015

Journal of Medical Virology

Volume 87Issue 12pages 2163–2167December 2015

Abstract below; full text is available to journal subscribers. 

A retrospective study to identify VAPP cases from the entire Uganda was conducted between January 2003 and December 2011. Eleven of the 106 AFP cases were VAPPs. The VAPP rate ranged from 0 to 3.39 cases per 1,000,000 birth cohorts and the peak was in 2009 when there was scaling up of OPV immunization activities following an importation of wild poliovirus in the country. All the subsequent polio suspect cases since then have been vaccine-associated polio cases. Our data support the strategy to withdraw OPV and introduce IPV progressively in order to mitigate against the paralysis arising from Sabin polioviruses. J. Med. Virol. 87:2163–2167, 2015. © 2015 Wiley Periodicals, Inc.

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