Tuesday, 2nd of August 2016 |
Vaccine. 2016 Jul 19;34(33):3803-9. doi: 10.1016/j.vaccine.2016.05.065. Epub 2016 Jun 16.
Effect of booster doses of poliovirus vaccine in previously vaccinated children, Clinical Trial Results 2013.
Habib MA1, Soofi S1, Mach O2, Samejo T1, Alam D1, Bhatti Z1, Weldon WC3, Oberste SM3, Sutter R2, Bhutta ZA4.
Abstract below; full text is available to journal subscribers.
BACKGROUND:
Considering the current polio situation Pakistan needs vaccine combinations to reach maximum population level immunity. The trial assessed whether inactivated poliovirus vaccine (IPV) can be used to rapidly boost immunity among children in Pakistan.
METHODS:
A five-arm randomized clinical trial was conducted among children (6-24months, 5-6years and 10-11years). Children were randomized in four intervention arms as per the vaccines they received (bOPV, IPV, bOPV+vitamin A, and bOPV+IPV) and a control arm which did not receive any vaccine. Baseline seroprevalence of poliovirus antibodies and serological immune response 28days after intervention were assessed.
RESULTS:
The baseline seroprevalence was high for all serotypes and the three age groups [PV1: 97%, 100%, 96%, PV2: 86%, 100%, 99%, PV3: 83%, 95%, 87% for the three age groups respectively]. There was significantly higher rate of immune response observed in the study arms which included IPV (95-99%) compared with bOPV only arms (11-43%), [p<0.001]; Vitamin A was not associated with improved immune response. Immune response rates in the IPV only arm and IPV+bOPV arm were similar [p>0.5].
CONCLUSION:
IPV has shown the ability to efficiently close existing immunity gaps in a vulnerable population of children in rural Pakistan.
Copyright © 2016 Elsevier Ltd. All rights reserved.
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