A male-determining factor in the mosquito Aedes aegypti
| Sunday, 4th of September 2016 |
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A male-determining factor in the mosquito Aedes aegypti
Manipulating M factor alters mosquito sex.
Excerpt below; full text is at http://d2ufo47lrtsv5s.cloudfront.net/content/348/6240/1268
Female mosquitoes feed on blood and in so doing transmit pathogens to millions annually. Althrough the molecular mechanism for determining sex in many animals is know, the specific factors in mosquitoes have been elusive. This is because sex determination in insects involves a section of the genome that is highly repetitive. Hall et al. now identify a male-detrmining factor (M factor) in Aedes aegypti. Manipulation of the M factor produced sex-change phenotypes. Knocking ou the gene Nix resulted in feminized males, and ectopic expression gave masculinized females. These findings should help to advance strategies for converting female mosquitoes into nonbiting males.
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