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Live Attenuated Chimeric Vaccine, rWN/DEN4Δ30 is Well-Tolerated and Immunogenic in Flavivirus-Naïve Older Adult Volunteers [West Nile Virus]

Thursday, 27th of October 2016

 

Live Attenuated Chimeric Vaccine, rWN/DEN4Δ30 is Well-Tolerated and Immunogenic in Flavivirus-Naïve Older Adult Volunteers

1. Kristen K. Pierce1,*,
2. Stephen S. Whitehead3,
3. Beth D. Kirkpatrick1,
4. Palmtama L. Grier2,
5. Adrienne Jarvis1,
6. Heather Kenney3,
7. Marya P. Carmolli1,
8. Cynthia Reynolds1,
9. Cecilia M. Tibery2,
10. Janece Lovchik2,
11. Anna Janiak2,
12. Catherine J. Luke3,
13. Anna P. Durbin2 and
14. Alexander G. Pletnev3

- Author Affiliations

1. ¹Vaccine Testing Center, Department of Medicine, University of Vermont College of Medicine, Burlington, VT 05405, USA
2. ²Center for Immunization Research, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
3. ³Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA

1. ↵*Correspondence: K. K. Pierce, Vaccine Testing Center, Department of Medicine, University of Vermont College of Medicine, 89 Beaumont Ave, Given Building C205, Burlington, VT 05405, Phone: 802-847-3819, Fax 802-847-5322 (Kristen.pierce@uvmhealth.org).

The Journal of Infectious Diseases

 

Abstract below; full text is available to journal subscribers.

West Nile virus (WNV), a major cause of mosquito-borne illness in the U.S. Human disease ranges from mild febrile illness to severe fatal neurologic infection. Adults over 60 are more susceptible to neuroinvasive disease accompanied by a high mortality rate or long-lasting neurologic sequelae. A chimeric live attenuated vaccine, rWN/DEN4Δ30, was shown to be safe and immunogenic in healthy adults ages 18-50. This study evaluated the rWN/DEN4Δ30 vaccine in flavivirus-naive adults age 50-65, and found it to be safe and immunogenic. Outbreaks of WNV tend to be unpredictable, a safe and effective vaccine will be an important public health tool.

• © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.