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Introduction of standard measles vaccination in an urban African community in 1979 and overall child survival: a reanalysis of data from a cohort study

Tuesday, 27th of December 2016

BMJ Open. 2016 Dec 20;6(12):e011317. doi: 10.1136/bmjopen-2016-011317.

Introduction of standard measles vaccination in an urban African community in 1979 and overall child survival: a reanalysis of data from a cohort study

Mogensen SW¹, Aaby P^1,2, Smedman L³, Martins CL¹, Rodrigues A¹, Benn CS^2,4, Ravn H^2,4.

• ¹Bandim Health Project, Indepth Network, Bissau, Guinea-Bissau.
• ²Research Centre for Vitamins and Vaccines (CVIVA), Bandim Health Project, Statens Serum Institut, Copenhagen, Denmark.
• ³Department of Womens and Childrens Health, Karolinska Institutet, Stockholm, Sweden.
• ⁴OPEN, Institute of Clinical Research, University of Southern Denmark/Odense University Hospital, Denmark.

Abstract below; full text is at http://bmjopen.bmj.com/cgi/pmidlookup?view=long&pmid=27998896

 

OBJECTIVE:

To examine the effect of the first introduction of measles vaccine (MV) in Guinea-Bissau in 1979.

SETTING:

Urban community study of the anthropometric status of all children under 6 years of age.

PARTICIPANTS:

The study cohort included 1451 children in December 1978; 82% took part in the anthropometric survey. The cohort was followed for 2 years.

INTERVENTION:

In December 1979, the children were re-examined anthropometrically. The participating children, aged 6 months to 6 years, were offered MV if they did not have a history of measles infection. There were no routine vaccinations in 1979-1980.

PRIMARY AND SECONDARY OUTCOME MEASURES:

Age-adjusted mortality rate ratios (MRRs) for measles vaccinated and not vaccinated children; changes in nutritional status.

RESULTS:

The nutritional status deteriorated significantly from 1978 to 1979. Nonetheless, children who received MV at the December 1979 examination had significantly lower mortality in the following year (1980) compared with the children who had been present in the December 1978 examination but were not measles vaccinated. Among children still living in the community in December 1979, measles-vaccinated children aged 6-71 months had a mortality rate of 18/1000 person-years during the following year compared with 51/1000 person-years for absent children who were not measles vaccinated (MRR=0.30 (0.12-0.73)). The effect of MV was not explained by prevention of measles infection as the unvaccinated children did not die of measles infection.

CONCLUSIONS:

MV may have beneficial non-specific effects on child survival not related to the prevention of measles infection.

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