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Long-term persistence of immunity after hepatitis B vaccination: A fact not a fancy

Wednesday, 4th of January 2017

Human Vaccines & Immunotherapeutics

Long-term persistence of immunity after hepatitis B vaccination: A fact not a fancy

Andrea Trevisan Department of Cardiologic, Thoracic and Vascular Sciences, Unit of Preventive Medicine and Risk Assessment, University of Padova, ItalyCorrespondenceandrea.trevisan@unipd.it

Page 00 | Received 10 Oct 2016, Accepted 02 Nov 2016, Accepted author version posted online: 01 Dec 2016

Page 00  

Received 10 Oct 2016

Accepted 02 Nov 2016

Accepted author version posted online: 01 Dec 2016

·         http://dx.doi.org/10.1080/21645515.2016.1257451

·         Accepted author version

Abstract

 

On the basis of an article previously published in the journal regarding immune persistence after hepatitis B vaccination in infancy, I discuss why this persistence is a fact and not a fancy. Immune memory after a primary vaccination series has been widely demonstrated by prompt response to booster doses and the proliferation of T cells secreting IFNγ. In a large cohort of medical students, 79% of subjects were positive for anti-HBs antibodies, and only 1.9% of the subjects had serological evidence of past hepatitis B infection. To prevent severe diseases, such as hepatitis B, it is very important that the majority of the population is vaccinated, especially those employed in health care, as vaccination is the most effective weapon to hepatitis B, which is still widespread worldwide.

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